Research papers

Ascencio Gutierrez, V., Martin, L.E., Simental Ramos, A., James, K.F., Medler, K.F., Schier, L.A., Torregrossa, A.M. (2024) TRPM4 and PLCβ3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCβ3 is not needed for taste-driven licking for glucose. Chem Senses doi: 10.1093/chemse/bjae001.

Dutta Banik., D and Medler, K.F. (2023) Defining the role of TRPM4 in broadly responsive taste receptor cells. Frontiers in Cellular Neuroscience doi: 10.3389/fncel.2023.1148995 

Moorhouse, A.J., Loats, A.E., Medler, K.F. and Roberts, S.G.E. (2022) The BASP1 transcriptional repressor modifies chromatin through lipid-dependent and lipid-independent mechanisms. iScience. 25(8):104796. doi: 10.1016/j.isci.2022.104796.

Loats, A.E., Carrera, S., Fleming, A.F., Roberts, A.R.E., Sherrard, A., Toska, E., Medler, K.F. and Roberts, S.G.E. (2021) Nuclear cholesterol is required for transcriptional repression by BASP1. PNAS 118 (29) e2101671118, doi: 10.1073/pnas.2101671118. 

Dutta Banik, D., Benfey, E.D., Martin, L.E, Kay, K.E., Loney, G.C., Nelson, A., Ahart, Z.C., Kemp, B.T., Kemp, B.R., Torregrossa, A.M. and Medler, K.F. (2020). A subset of broadly responsive Type III taste cells contributes to the detection of bitter, sweet, and umami stimuli. PLoS Genet 16 (8): e1008925; doi: 10.1371/journal.pgen.1008925.  This paper was highlighted in multiple news outlets, including: Newsweek, Eurekalert.org; Sci-news.com; the Daily Mail, Google News, Science News, Biocompare, Brain Post, Neo.Life, New Atlas, People Behind the Science and others.  This work was highlighted in “Twenty UB research stories from 2020”

Ahart, Z.A., Martin, L.E., Kemp, B.R., Dutta Banik, D., Roberts, SGE., Torregrossa, A.M., Medler, K.F. (2020) Differential effects of diet and weight on taste responses in diet-induced obese mice. Obesity (2):284-292. doi: 10.1002/oby.22684. 

Gao, Y., Dutta Banik, D., Muna, M., Roberts,SGE., Medler, K.F. (2019) The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells.  Life Science Alliance 2(3): e201800287. doi: 10.26508/lsa.201800287. 

Dutta Banik, D., Martin, L.E. Freichel, M., Torregrossa, A.M. and Medler, K.F. (2018)  TRPM4 and TRPM5 are both required for the normal detection of bitter, sweet and umami stimuli in taste receptor cells. PNAS, doi: 10.1073/pnas.1718802115. This paper was highlighted in multiple news outlets.  I was also invited to write up this work in The Conversation and Baking Europe.  I gave interviews to the Institute of Food Technologies and Food Processing Technology that resulted in publications in their magazines.  This article was also written up for the Faculty of 1000 Prime. 

Marsh, L., Carerra, S., Shandilya, J., Heesom, K., Davidson, A., Medler, K.F., and Roberts SGE. (2017) BASP1 interacts with Estrogen receptora and modifies the  tamoxifen response. Cell Death and Disease 8(5):e2771. doi: 10.1038/cddis.2017.179.

Shandilya, J., Gao, Y., Nayak, T., Roberts, S.G.E., and Medler, K.F. (2016)  AP1 transcription factors regulate taste cell maintenance during aging. Cell Death and             Disease 7(10):e2433. doi: 10.1038/cddis.2016.343. 

Shandilya J., Medler K.F., and Roberts S.G.E. (2016) Regulation of AURORA B function by mitotic checkpoint protein MAD2.Cell Cycle. 24:1-6/27341405. doi: 10.1080/15384101.2016.1200773. 

Gao, Y. *, Toska, E. *, Denmon, D., Roberts, S.G.E., and Medler, K.F. (2014) WT1 regulates the development of the posterior taste field.  Development 141: 1-8 doi:10.1242/dev.105676. *Co-first authors. 

Shandilya, J., Toska, E., Richard, D., Medler, K.F., and Roberts, S.G.E. (2014) WT1 Interacts with Mad2 and Regulates Mitotic Checkpoint Function. Nature Communications. 5:4903. doi: 10.1038/ncomms5903. 

Toska, E., Shandilya, J., Goodfellow, S.J., Medler, K.F., and Roberts, S.G.E. (2014) Prohibitin is required for transcriptional repression by the WT1-BASP1 complex. Oncogene 33:5100-5108. doi: 10.1038/onc.2013.447. 

Maliphol, A.B., Garth, D.J., and Medler, K.F. (2013) Diet-induced obesity reduces the responsiveness of the peripheral taste system. PLoS ONE 8(11):e79403. This paper was featured in NPR’s Academic Minute; Buffalo News; Women’s Health; BBC Mundo; La Figaro; UK Daily Mail; CBC Broadcasts; Scientist of the Week, Laboratory Equipment; Noticias de la Ciencia y la Tecnologia; Nature World News; Medical Daily, plus multiple health websites.

Rebello, M.R., Maliphol, A.B., and Medler, K.F. (2013) Ryanodine receptors selectively interact with L type calcium channels in mouse taste cells. PLoS ONE 8(6):e68174. 

Toska, E., Campbell, H.A., Shandilya, J., Goodfellow, S.J., Shore, P., Medler, K.F., and Roberts, S.G.E.  (2012) Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of Histone Deacetylase.  Cell Reports 2(3):462-9. doi: 10.1016/j.celrep.2012.08.005. 

Rebello, M. R., Aktas, A. and Medler, K.F. (2011) Expression of calcium binding proteins in mouse taste receptor cells.  J. Histo & Cyto. 59(5): 530-539. 

Goodfellow, S.J., Rebello, M.R., Toska, E., Zeef,L., Rudd, S., Medler, K.F., and Roberts, S.G.E.  (2011) WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line.  Biochemical Journal 435(1):113-25. 

Starostik, M.R.#, Rebello, M.R., Cotter, K.A. #, Kulik, A. and Medler, K.F.  (2010) Expression of GABAergic receptors in mouse taste receptor cells.  PLoS ONE 5(10): e13639. 

Rebello, M. R. and Medler, K.F. (2010) Ryanodine receptors selectively contribute to taste evoked responses in mouse taste receptor cells.  Eur. J. Neurosci.  32(11): 1825-1835. 

Szebenyi, S.A., Laskowski, A.I., and Medler, K.F. (2010) Sodium/calcium exchangers selectively regulate calcium signaling in mouse taste receptor cells. J. Neurophys. 104: 529-538.  

Laskowski, A.I. and Medler, K.F. (2009) Sodium/calcium exchangers contribute to the regulation of cytosolic calcium levels in mouse taste cells. J. Physiol. 587(16): 4077-4089.*selected for Faculty of 1000 Biology* 

Hacker, K. and Medler, K.F. (2008) Mitochondrial calcium buffering contributes to the maintenance of basal calcium levels in mouse taste cells. J. Neurophys.100(4):2177-91 The previous two papers were highlighted in “Examining the neglected side of calcium regulation in taste cells” by R Dando J Physiol 587.23 (2009) 5523-5524.

Hacker, K., Laskowski, A., Feng, L., Restrepo, D. and Medler, K. (2008) Evidence for two populations of bitter responsive taste cells in mice.  J Neurophys 99(3): 1503-14. 

Clapp, T.R., Medler, K.F., Damak, S., Margolskee R.F., and Kinnamon, S.C.  (2006)  Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25.  BMC Biology 4(1):7 *highly accessed designation. 2

Medler, K., Margolskee, R.F., and Kinnamon, S.C. (2003)  Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice.  J. Neurosci. 23(7):2608-2617.

Medler, K. and Gleason, E. (2002) Mitochondrial Ca2+ buffering regulates synaptic transmission between retinal amacrine cells.  J. Neurophysiol. 87: 1426-1439. Kreimborg, K., Lester, M., Medler, K. and Gleason, E. (2001) Group I metabotropic glutamate receptors are expressed in the chicken retina and by cultured retinal     amacrine cells.  J. Neurochem. 77: 452-465. 

Medler, K. and Bruch, R.  (1999) Protein kinase C b and d selectively phosphorylate odorant and metabotropic glutamate receptors.  Chem. Senses 24: 295-299. 

Medler, K., Hansen, A. and Bruch, R.  (1998) Odorant receptor gene expression in catfish taste tissue.  NeuroReport 9(18): 4103-4107.

Medler, K., Tran, H., Parker, J., Caprio, J., and Bruch, R.  (1998) Metabotropic glutamate receptor expression in olfactory receptor neurons from the channel catfish, Ictalurus punctatus.  J. Neurobiology 35: 94-104. 

Medler, K. and Lance, V. (1998) Sex differences in plasma corticosterone levels in alligator (Alligator mississippiensis) embryos. J. Exp. Zool. 280(3): 238-244. 

Bruch, R., Kang, J., Moore, M., and Medler, K. (1997) Protein kinase C and receptor kinase gene expression in olfactory receptor neurons.  J. Neurobiology 33: 387-394. Bruch, R., Medler, K., Tran, H. , and Hamlin, J.  (1997) G protein ßg subunit enes expressed in olfactory receptor neurons.  Chem. Senses 22: 587-592. 

Heck, J., MacKenzie, D., Rostal, D., Medler, K., and Owens, D. (1997) Estrogen  induction of plasma vitellogenin in the Kemp's Ridley sea turtle (Lepidochelys kempi).  Gen. & Comp. Endocrin. 107: 280-288. 

Bruch, R., and Medler, K. (1996) A regulator of G protein signaling in olfactory receptor neurons.  NeuroReport 7:2941-2944.

Pratt, N., Alberts, A., Phillips, J., and Fulton-Medler, K.  (1992)  Behavioral, physiological and morphological components of dominance and mating attraction in male green iguanas.  Zoo Biology 11: 53-63. 

Book Chapters

Dutta Banik, D., and Medler, K.F. (In review) Nutrient sensing by lingual G-protein coupled taste receptors.  Invited chapter in “Nutrient Sensing in Eukaryotes” (Methods in Molecular Biology)” Editors: Fiona Russell and Grahame Hardie.

Dutta Banik, D., and Medler, K.F. (2021) Taste Receptor Signaling.  Invited chapter in “The Pharmacology of Taste (Handbook of Experimental Pharmacology)” doi: 10.1007/164_2021_442.  Editors: Kyle Palmer and Guy Servant. 

Medler, K.F. (2015) Taste cells and calcium signaling.  Invited chapter in “Calcium: Chemistry, Analysis, Function, and Effects” for Food and Nutritional Components in Focus.  Editor:  Professor Victor R Preedy.  Published by Royal Society of Chemistry

Medler, K.F. (2011) Multiple roles for TRPs in the taste system: Not your typical TRPs. Invited chapter in “The Transient receptor potential channels” for the Advances in Experimental Medicine and Biology 704:831-46.  Editor: Dr. Md. Shahidul Islam. Published by Springer, Inc

Medler, K., and Kinnamon,  S.C.  (2004) Transduction channels in Taste Cells.  Invited chapter in “Transduction Channels in Sensory Cells” Eds. Frings and Bradley. Published by Wiley-VCH. pp. 153-177.        

Invited Review Articles & Commentaries

Ferrario CR, Münzberg-Gruening H, Rinaman L, Betley JN, Borgland SL, Dus M, Fadool DA, Medler KF, Morton GJ, Sandoval DA, de La Serre CB, Stanley SA, Townsend KL, Watts AG, Maruvada P, Cummings D, Cooke BM (2024). Obesity- and diet-induced plasticity in systems that control eating and energy balance. Obesity doi: 10.1002/oby.24060.

Dutta Banik, D. and Medler, K.F. (2021) Bitter, sweet, and umami signaling in taste cells: It’s not as simple as we thought. Invited refereed review in Current Opinion in Physiology. doi.org/10.1016/j.cophys.2021.01.010

Medler, K.F. (2018) Taste: It’s not as simple as we think. Invited article for Baking Europe, Spring 2018.

 Medler, K.F. (2015) Honing in on the ATP release channel in taste cells.  Invited Commentary for Chemical Senses. doi: 10.1093/chemse/bjv035

 Medler, K.F. (2014) Calcium signaling in Taste cells.  Invited refereed review for BBA-Molecular Cell Research. 10.1016/j.bbamcr.2014.11.013

 Medler, K.F. (2010) Calcium signaling in taste cells:  Regulation Required.  Invited refereed review for Chemical Senses. 35(9):753-65

 Medler, K.F.  (2008) Signaling mechanisms controlling taste cell function.  CREGE, 18 (2):125-137